Hydrochloric Acid → HCID 9902129, compound

Participants

Reaction Steps

A mixture of 6-cyano-2-(4-fluorophenyl)-3-(4-pyridinyl)pyrazolo[1,5-a]pyridine (Example 52. 100 mg, 0.318 mmol) and concentrated hydrochloric acid (2 mL) were stirred at room temperature overnight. The mixture was diluted with ether, basified with 5N sodium hydroxide solution and extracted thoroughly with ethyl acetate several times. The combined organic layers were dried (MgSO4), filtered and evaporated to dryness. The title compound was isolated in 85% yield (90 mg). 1H NMR (d6-DMSO) δ 9.36 (s, 1H), 8.60 (d, 2H, J=5.2 Hz), 8.22 (bs, 1H), 7.81 (bs, 2H), 7.67 (bs, 1H), 7.58 (m, 2H), 7.28–7.37 (m, 4H). MS (ES+ve): 334 (25, M+2), 333 (100, M+1).

Provenance & Evidence