1-Pyrrolidineethanamine → HCID 10162279, compound

Participants

Reaction Steps

2-Pyrrolidin-1-ylethylamine (0.04 mL) and 4-[2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-yl methyl sulfone (0.02 g) were mixed at room temperature and heated with an airgun until a homogenous melt was obtained (2 min). Upon cooling, water was added. The precipitated solid was filtered and dried to give the title compound as a beige solid (0.012 g); 1H NMR (CDCl3) δ 8.83(1H, s), 8.51(1H, d), 8.11(1H, d), 7.63(2H, dd), 7.43 (1H, dd), 7.15(2H, dd), 6.33(1H, d), 5.75(1H, bs), 3.58(2H, dt), 2.76(2H, t), 2.58(2H, bt), 1.81(2H, bm); m/z 471 (M+1)+.

Provenance & Evidence