1-Pyrrolidineethanamine → HCID 10229042, compound

Participants

Reaction Steps

2-Pyrrolidin-1-ylethylamine (0.04 mL) and 4-[2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-yl methyl sulfone (0.02 g) were mixed at room temperature and heated with an airgun until a homogenous melt was obtained (2 min). Upon cooling, water was added. The precipitated solid was filtered and dried to give the title compound as a beige solid (0.012 g); 1H NMR (d6-DMSO) δ 9.50(1H, s), 8.48(1H, bs), 8.18(1H, d), 7.83(1H, d), 7.68(1H, dd), 7.62(1H, m), 7.56(1H, dd), 7.12(1H, bs), 6.42(1H, bs), 2.44(2H, bs), 1.67(4H, bs); m/z 505 (M+1)+.

Provenance & Evidence