Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | 3-Iodo-p-toluidine | HCID 118889 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 22054484 | HCID 22054484 | 81.3% |
Reaction Steps
A mixture of diethyl malonate (16.0 g, 100 mmol) and 3-iodo-4-methylaniline (46.6 g, 200 mmol) was heated at 210° C. for 20 min, allowing the liberated ethanol to evaporate. After cooling the solid formed was triturated in hot ethanol (200 mL) to afford the title compound (43.4 g, 81%). Light brown solid, ISP-MS: m/e=535.0 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07166589B2 |
|---|
| Source dataset | uspto-grants-2007_01 |
|---|
| ORD ID | ord-d4008181f86640c29f7a51d076f5695f |
|---|
| Source note | uspto-grants-2007_01 |
|---|
