HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 7-Iodo-6-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 7-Iodo-6-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester | HCID 69471668 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 7-Iodo-6-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid | HCID 22054488 | 99% |
Reaction Steps
A suspension of 7-iodo-6-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (8.30 g, 23.2 mmol) in 2 M aq. sodium hydroxide solution (80 mL) was heated at reflux for 2 h. After cooling the solution obtained was acidified with 25% aq. hydrochloric acid solution. The precipitate was collected by filtration and dried to afford the title compound (7.56 g, 99%). White solid, ISN-MS: m/e=327.9 ([M−H]−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07166589B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-5d4b6ff8009144f6947526a580f0ec16 |
| Source note | uspto-grants-2007_01 |