Water → HCID 68807570, compound

Participants

Reaction Steps

The 14,15-epoxide (24) (300 mg, 0.77 mmol) in dry tetrahydrofuran (10 ml) is added to a suspension of lithium aluminium hydride (300 mg, 7.89 mmol) in tetrahydrofuran and the reaction refluxed for 48 h. After the addition of water (0.3 ml), sodium hydroxide (15% soln, 0.3 ml) and filtration as described earlier, the mixture is purified by silica gel column chromatography using methanol:chloroform (1:9) as solvent to give the trihydroxy pregnene (25) (250 mg, 83%).

Provenance & Evidence