HCID 68807570, compound → HCID 69504664, compound

HRID 1374784Notes

Reaction equation

HRID 1374784 reaction equation
[OH:1][C@H:2]1[CH2:24][CH2:23][C@@:22]2([CH3:25])[C:4](=[CH:5][CH2:6][C@@H:7]3[C@@H:21]2[CH2:20][C@@H:19]([OH:26])[C@@:18]2([CH3:27])[C@:8]3([OH:28])[CH2:9][CH2:10][C@@H:11]2[C:12]2(OCCO2)[CH3:13])[CH2:3]1>C(O)(=O)C>[OH:1][C@H:2]1[CH2:24][CH2:23][C@@:22]2([CH3:25])[C:4](=[CH:5][CH2:6][C@@H:7]3[C@@H:21]2[CH2:20][C@@H:19]([OH:26])[C@@:18]2([CH3:27])[C@:8]3([OH:28])[CH2:9][CH2:10][C@@H:11]2[CH2:12][CH3:13])[CH2:3]1

Participants

3

Reactant 1

HCID 68807570HCID 68807570, compound

Product 1

HCID 69504664HCID 69504664, compoundYield 93.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The ethylenedioxypregnene (25) (250 mg, 0.64 mmol) is dissolved in acetic acid (13.4 ml) and water which after freeze drying affords the trihydroxy steroid (15) (200 mg, 89%), m.p.: 228°–235° C. (lit. 225°–235° C.), M+348, [αD]20 +35° (lit [αD]20+29°).

Workup

  1. dry with materialwater which after freeze drying

Sources & evidence

ORD record
ord-724f80660c814d04928d93522ddc55a4
Source dataset
uspto-grants-2007_01
Patent number
US07166611B2

Reaction notes

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