Ethyl bromoacetate → HCID 86599795, compound

Participants

Reaction Steps

A stirred solution of 3-[(4-chlorophenyl)thio]-2,5-dimethyl-1H-indole (300 mg) in dry N,N-dimethylformamide (15 ml) was treated with sodium hydride (42 mg of a 60% dispersion in mineral oil). After 10 minutes the reaction was treated with ethyl bromoacetate (116 μl) and stirring continued for 24 hours. The reaction was poured into distilled water (200 ml) and extracted with diethyl ether (3×100 ml). The extracts were dried (MgSO4), evaporated in vacuo and the residue purified by flash column chromatography eluting with 10% ethyl acetate in iso-hexane. The subtitle compound was obtained as a yellow solid (yield 130 mg).

Provenance & Evidence