Phosphorus pentachloride → Pyridine-3-sulfonyl chloride hydrochloride

HRID 1374821Notes

Reaction equation

HRID 1374821 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([S:7]([OH:10])(=O)=[O:8])[CH:2]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:12]>>[ClH:12].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([S:7]([Cl:12])(=[O:10])=[O:8])[CH:2]=1

Participants

3

Reactant 2

HCID 24819Phosphorus pentachloride2×HCID 694683-Pyridinesulfonic acid

Product 1

HCID 12571517Pyridine-3-sulfonyl chloride hydrochloride

Procedure

1 g (6.3 mmol) of pyridine-3-sulphonic acid and 1.4 g (6.7 mmol) of phosphorus pentachloride are stirred for 2 hours at 150° C. After cooling, excess phosphorus pentachloride is eliminated in vacuo. The crude product is further reacted immediately.

Workup

  1. temperatureAfter cooling

Sources & evidence

ORD record
ord-80c17102bece4f91b0912e4d9f42b274
Source dataset
uspto-grants-2007_01
Patent number
US07166615B2

Reaction notes

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