4-Fluoroaniline → 3-chloro-N-(4-fluorophenyl)propanamide

HRID 1374838Notes

Reaction equation

[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[Cl:9][CH2:10][CH2:11][C:12](Cl)=[O:13]>>[Cl:9][CH2:10][CH2:11][C:12]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([F:1])=[CH:3][CH:4]=1)=[O:13]

Participants

Reactant 2

HCID 97314-Fluoroaniline

HCID 693643-Chloropropionyl chloride

Product 1

HCID 5320563-chloro-N-(4-fluorophenyl)propanamide

Procedure

By using 4-fluoroaniline and 3-chloropropionyl chloride, the title compound was obtained by similar procedures to those of Example 42a (yield: 57%).

Sources & evidence

ORD record: ord-f771372f90bb46d581cdf2ebd7b286dc
Source dataset: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07166617B2

Reaction notes

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