Dichloromethane → tert-butyl 5-chloro-1-(7-fluoro-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[2H-indole-3,4'-piperidine]-1'-carboxylate

HRID 137486Notes

Reaction equation

HRID 137486 reaction equation
[CH2:34]([N:35]([S:36]([F:37])([F:38])[F:40])[CH2:39][CH3:41])[CH3:42].[Cl:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[N:7]([c:11]1[c:12]3[c:13]([n:14][cH:15][n:16]1)[CH:17]([OH:21])[CH2:18][CH:19]3[CH3:20])[CH2:6][C:5]21[CH2:22][CH2:23][N:24]([C:27](=[O:28])[O:29][C:30]([CH3:31])([CH3:32])[CH3:33])[CH2:25][CH2:26]1.[Cl:43][CH2:44][Cl:45]>>[Cl:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[N:7]([c:11]1[c:12]3[c:13]([n:14][cH:15][n:16]1)[CH:17]([F:40])[CH2:18][CH:19]3[CH3:20])[CH2:6][C:5]21[CH2:22][CH2:23][N:24]([C:27](=[O:28])[O:29][C:30]([CH3:31])([CH3:32])[CH3:33])[CH2:25][CH2:26]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 123472(Diethylamino)sulfur trifluorideHCID 178428895HCID 178428895, compound

Product 1

HCID 178427816tert-butyl 5-chloro-1-(7-fluoro-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[2H-indole-3,4'-piperidine]-1'-carboxylate

Sources & evidence

ORD record
ord-5db3f8b304af457faae25317fc28bd30
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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