Diethyl (ethoxymethylene)malonate → HCID 58783534, compound

Participants

Reaction Conditions

Reaction Steps

Following the procedure of Veale, J. Org. Chem., 58,4490 (1993), to [1-(N-Benzyl-carbamimidoyl)-2-methyl-propyl]-carbamic acid tert-butyl ester (10.86 g, 35.6 mmol) in methanol (160 mL) was added diethyl ethoxymethylenemalonate (7.7 g, 35.6 mmol). The reaction is equipped with a Dean-Stark trap. The reaction was heated at 100° C. until all solvent was removed. The residue was dissolved in methylene chloride, washed with 1 N HCl and water, dried (Na2SO4), and concentrated. The resulting pale yellow syrup was used in the next step without further purification.

Provenance & Evidence