Methanol → HCID 69331780, compound

Participants

Reaction Steps

Thionyl chloride (0.7 ml) was added dropwise to a solution of 3-methoxy-4-methyl-D-phenylalanine hydrochloride (1.75 g) in methanol (8 ml) over 10 minutes at room temperature. The whole was stirred at 40–50° C. for 2 hours and then an additional thionyl chloride (0.7 ml) was added to the mixture. The whole mixture was stirred for further 1 hour and evaporated under reduced pressure. The resulting solid was triturated with diisopropyl ether and collected by filtration to give colorless crystals of 3-methoxy-4-methyl-D-phenylalanine methyl ester hydrochloride (1.70 g).

Provenance & Evidence