反应详情

To a solution of 4-fluoro-3-methoxybenzaldehyde (5 g) in methanol (25 ml) was added dropwise sodium borohydride (368 mg) in 0.1N sodium hydroxide aqueous solution (5 ml) in water bath and the whole was stirred for 1 hour. After the mixture was evaporated under reduced pressure, ethyl acetate and water were added thereto. The organic layer was separated and the water layer was further extracted with ethyl acetate. The combined organic layer was dried over magnesium sulfate and concentrated in vacuo to give 4-fluoro-3-methoxybenzyl-alcohol (5.22 g) as an oil.

1. customAfter the mixture was evaporated under reduced pressure, ethyl acetate and water
2. additionwere added
3. customThe organic layer was separated
4. extractionthe water layer was further extracted with ethyl acetate
5. dry with materialThe combined organic layer was dried over magnesium sulfate
6. concentrationconcentrated in vacuo