Hydrochloric Acid → HCID 86602698, compound

Participants

Reaction Steps

(2R)-1-[3,5-Bis(trifluoromethyl)benzoyl]-2-(3-hydroxy-4-methylbenzyl)-4-[4-[(2S)-2-(methoxymethyl)morpholino]-2-butynyl]piperazine (0.05 g) in ethyl acetate (5 ml) was treated with 4N hydrogen chloride in ethyl acetate (1 ml) and the mixture was concentrated under reduced pressure. After the residue was triturated with a mixture of dichloromethane and diisopropyl ether, the organic solvents were removed under reduced pressure to give (2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3-hydroxy-4-methylbenzyl)-4-[4-[(2S)-2-(methoxymethyl)morpholino]-2-butynyl]piperazine dihydrochloride (0.05 g) as a powder.

Provenance & Evidence