Hydrochloric Acid → HCID 69419423, compound

Participants

Reaction Steps

To a solution of (2R)-2-(3-tert-butyldiphenylsilyloxy-4-methylbenzyl)-4-[2-[(2S)-2-(methoxymethyl)morpholino]ethyl]-piperazine (9.38 g) in ethyl acetate (40 ml) was added 4N hydrogen chloride in ethyl acetate (11.7 ml) at 0° C. and then added dropwise hexane (200 ml). After stirring at room temperature for 2 hours, the mixture was cooled at 0° C. The resulting precipitates were collected by filtration, washed with hexane, and dried under reduced pressure to give (2R)-2-(3-tert-butyldiphenylsilyloxy-4-methylbenzyl)-4-[2-[(2S)-2-(methoxymethyl)morpholino]ethyl]piperazine trihydrochloride (10.75 g) as a powder.

Provenance & Evidence