反应详情

温度

40 °C

To a solution of 5-(2-hydroxyethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (0.49 g) in dichloromethane (20 ml) was added dropwise thionyl chloride (0.39 ml). The mixture was stirred at 40° C. for 1.5 hours. After the mixture was evaporated under reduced pressure, the residue was triturated with diisopropyl ether. The resulting powder was collected by filtration, washed with diisopropyl ether and dried in vacuo to give 5-(2-chloroethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride (0.44 g).

1. customAfter the mixture was evaporated under reduced pressure
2. customthe residue was triturated with diisopropyl ether
3. filtrationThe resulting powder was collected by filtration
4. washwashed with diisopropyl ether
5. customdried in vacuo