反应详情

温度

70 °C

A mixture of 2,5-bis(hydroxymethyl)tetrahydrofuran bis(p-toluenesulfonate) (10 g) and benzylamine (9.7 g) was stirred at 70° C. for 24 hours. To the mixture was added a solution of sodium hydroxide (1.85 g) in methanol (30 ml). After stirring at room temperature for 30 minutes, the mixture was filtered. The filtrate was evaporated, added dichloromethane, and filtered. The filtrate was evaporated under reduced pressure, and purified with column chromatography (silica gel, 250 ml, ethyl acetate:hexane=1:4) to give 3-benzyl-8-oxa-3-azabicyclo[3.2.1]octane (4.05 g) as an oil.

1. stirringAfter stirring at room temperature for 30 minutes
2. filtrationthe mixture was filtered
3. customThe filtrate was evaporated
4. additionadded dichloromethane
5. filtrationfiltered
6. customThe filtrate was evaporated under reduced pressure
7. custompurified with column chromatography (silica gel, 250 ml, ethyl acetate:hexane=1:4)