Water → HCID 9836534, compound

Participants

Reaction Steps

To the mixture of 3c (30 mg, 0.11 mol) in CH2Cl2 (10 mL) was added chlorosulfonyl isocyanate (14 μL, 0.165 mmol). The resultant mixture was stirred at room temperature for 3 h, then mixed with water (0.5 mL). Separation using a reverse phase HPLC afforded 3d (20 mg, 58%) as a white solid: MS (ES) 316 (M+H)+; 1H NMR (400 MHz, CD3OD) δ8.02 (s, 1 H), 7.69 (m, 2 H), 7.20 (m, 2 H).

Provenance & Evidence