反应详情

A solution of (2-(4-(2-(2-o-tolylamino-benzoxazol-6-yl)-acetylamino)-phenyl)-indan-2-yl)-acetic acid ethyl ester [0.297 g, Reference Example 9(a)] in ethanol (10 mL) was treated with aqueous sodium hydroxide (1.61 mL, 1N) and the mixture was heated at reflux temperature for 6 hours and then left at room temperature overnight and then evaporated. The residue was treated with water (30 mL) and the resulting mixture was acidified to pH 1 by addition of hydrochloric acid (1N) then extracted with ethyl acetate. The ethyl acetate extract was dried over magnesium sulfate and then evaporated. The residue was dissolved in hot acetonitrile and the solution was treated with charcoal then filtered. The filtrate was evaporated to give the title compound (0.07 g) as a biscuit coloured solid.

1. temperaturethe mixture was heated
2. temperatureat reflux temperature for 6 hours
3. customevaporated
4. additionThe residue was treated with water (30 mL)
5. additionthe resulting mixture was acidified to pH 1 by addition of hydrochloric acid (1N)
6. extractionthen extracted with ethyl acetate
7. extractionThe ethyl acetate extract
8. dry with materialwas dried over magnesium sulfate
9. customevaporated
10. dissolutionThe residue was dissolved in hot acetonitrile
11. additionthe solution was treated with charcoal
12. filtrationthen filtered
13. customThe filtrate was evaporated