Sodium Hydroxide → HCID 10278603, compound

Participants

Reaction Steps

A solution of (4-(4-{2-[2-o-tolylamino-benzoxazol-6-yl]-acetylamino}-phenyl)-tetrahydro-pyran-4-yl)-acetic acid methyl ester [0.2 g, Reference Example 17(b)] in ethanol (25 mL) was treated with sodium hydroxide solution (2 mL, 1N) and the mixture was stirred under argon and at reflux temperature for 3 hours. The reaction mixture was evaporated and the residue was dissolved in water (25 mL). This solution was washed with diethyl ether (10 mL) and then acidified to pH 1 by addition of hydrochloric acid (3 mL, 1N). The resulting precipitate was filtered, then washed four times with water (5 mL) and then dried at 60° C. under high vacuum to give the title compound (0.1 g) as an off-white solid. LC-MS: RT=3.10 minutes, MS(ES+): 500(M+H)+.

Provenance & Evidence