Dichloromethane → HCID 10141610, compound

Participants

Reaction Steps

[1-{4-[2-[4-Methyl-2-o-tolylamino-benzoxazol-6-yl]-acetylamino]-phenyl}-cyclopentyl]-acetic acid tert-butyl ester [0.065 g, Reference Example 1(d)] was treated with a mixture of trifluoroacetic acid (2.2 mL), dichloromethane (0.5 mL) and water (0.25 mL). The resultant solution was stirred at room temperature, under argon, for 1.5 hours and then the colourless solution was evaporated. The residue was chased twice with toluene (15 mL) to yield a clear gum. This gum was triturated with pentane and the solid obtained was washed with pentane and then dried at 60° C., under vacuum, to give the title compound (0.25 g) as an off-white solid, m.p. softens at 110° C. then slowly melts from 120–150° C.

Provenance & Evidence