反应详情

温度

50 °C

A stirred solution of [2-(4-acetylamino-phenyl)-1,3-dihydroxy-indan-2-yl]-acetic acid ethyl ester (0.38 g, Reference Example 12) in acetic acid (20 mL), under nitrogen, was treated with palladium black (20 mg), then the flask was evacuated and then hydrogen was introduced into the flask via a balloon. After stirring at 50° C. for 2 days the reaction mixture was filtered through Hi-flow supercel. The filtrate was concentrated then diluted with ethyl acetate (100 mL). This solution was washed with saturated sodium hydrogen carbonate solution (100 mL), then with water (100 mL), then dried over magnesium sulfate and then evaporated to give the title compound (0.296 g) as an amber coloured gum.

1. customthe flask was evacuated
2. additionhydrogen was introduced into the flask via a balloon
3. filtrationwas filtered through Hi-flow supercel
4. concentrationThe filtrate was concentrated
5. additionthen diluted with ethyl acetate (100 mL)
6. washThis solution was washed with saturated sodium hydrogen carbonate solution (100 mL)
7. dry with materialwith water (100 mL), then dried over magnesium sulfate
8. customevaporated