Sodium Iodide → [2-(4-Acetylamino-phenyl)-1,3-dioxo-indan-2-yl]-acetic acid ethyl ester

Participants

Reaction Conditions

Reaction Steps

A solution of sodium (0.412 g) in absolute ethanol ((200 mL) was treated with 2-(4-acetylaminophenyl)-indan-1,3-dione (5 g, Reference Example 14) then with sodium iodide (2.69 g) and chloroacetic acid ethyl ester (3.6 mL). The mixture was heated at 100° C. for 20 minutes then poured into water (500 mL) and then extracted with ethyl acetate (500 mL). The organic extract was dried over magnesium sulfate and then evaporated to give the title compound (5.25 g) as a pale coloured solid.

Provenance & Evidence