Methyl chloroacetate → HCID 14911858, compound

Participants

Reaction Steps

86 g of potassium tert-butylate was dissolved in 150 ml of dimethyl acetamide and 100 g of acetoacetic acid ethyl ester was added drop by drop with stirring. Subsequently, 83 g of chloroacetic acid methyl ester was added dropwise. When the exothermic reaction ended, 5 g of potassium tert-butylate and 5 g of chloroacetic acid methyl ester were added alternately until conversion was complete. The solid was filtered off and washed with ethyl acetate. Fractional distillation yielded 30 g of 3-acetyl-3-(ethoxycarbonyl)-pentanedioic acid dimethyl ester (purity: 91%; colorless).

Provenance & Evidence