HuagongsheHuagongshe Chemistry Print Report · For research reference only
Maleic Acid → Maleate(2-)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Maleic Acid | HCID 444266 | — |
| Reactant | Tivozanib | HCID 9911830 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Maleate(2-) | HCID 5288227 | — |
| Product | Tivozanib | HCID 9911830 | — |
Reaction Steps
said process comprising the steps of: adding methanol to N-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(5-methyl-3-isoxazolyl)urea, adding a solution of maleic acid in methanol dropwise thereto, stirring the mixture to give a maleate of N-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(5-methyl-3-isoxazolyl)urea, and
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07166722B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-4633352dd8f44f6fab337bc96f325223 |
| Source note | uspto-grants-2007_01 |