HCID 21078694, compound → HCID 10335343, compound

Participants

Reaction Steps

A standard hydrogenation bottle was charged with 3-nitro-4-chloro-N-[(1S,2S)-1-(hydroxymethyl)-2-methylbutyl]benzenesulfonamide (0.50 g, 1.48 mmol), 10% palladium on carbon (0.05 g), methanol (25 mL) and hydrogen gas. It was shaken on a Parr hydrogenation apparatus for 50 minutes. The reaction mixture was filtered and the solvent evaporated to produce a crude oil that was flash chromatographed (eluant: ethyl acetate-hexane, 3–2) to afford the product as a solid, mp 89–92° C. (0.12 g, 26%). MS (+APCI) 307.03 ([M+H]+). Anal. Calc'd for C12H19ClN2O3S: C, 46.98; H, 6.24; N, 9.13; Found: C, 47.44; H, 6.32; N, 8.88.

Provenance & Evidence