1,3,5-Triiodo-2,4,6-trimethylbenzene → 3,5-Dioxohexanoic acid

関与物質

反応手順

Triiodomesitylene is converted under acetylating conditions in an oxidation reaction with potassium permanganate/acetic anhydride/acetic acid/sulfuiric acid into triacetate (yield: 35%). The triacetate is isolated and saponified with potassium carbonate in methanol to tris alcohol (yield: 94%). The tris alcohol is then reacted to form tris aldehyde by Swem oxidation in dimethyl sulfoxide as a solvent in a yield of 67%.

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