反应详情

A solution of 10.2 g (15.5 mmol) N-[4′-(tert-butyl-diphenyl-silanyloxy)-3′-methoxy-biphenyl-2-yl]-2-(4-chlorophenyl)-2-prop-2-ynyloxy-acetamide and 24.5 g (77.5 mmol) tetrabutylammonium fluoride in 200 ml of dichloromethane is stirred for 4 hours at room temperature. After extracting with water/ethyl acetate and evaporation of the organic phase, the residue is subjected to flash-chromatography (ethyl acetate/hexane 4:6). Yield: 2-(4-chlorophenyl)-N-(4′-hydroxy-3′-methoxy-biphenyl-2-yl)-2-prop-2-ynyloxy-acetamide, m.p. 140–142° C.

1. extractionAfter extracting with water/ethyl acetate and evaporation of the organic phase