3-(Trifluoromethyl)phenol → HCID 21079531, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of m-CF3C6H4OH (48.6 g, 0.30 mol), epichlorohydrin (138.8 g, 1.50 mol) and K2CO3 (20.7 g, 0.15 mol) was stirred at 70° C. for 2 h. Epichlorohydrin was evaporated in vacuo. Water (250 mL) was added and the resulting mixture was extracted with CH2Cl2 (2×50 mL). The combined organic extract was stirred with 32% HCl (50 mL) for 0.5 h at rt. The organic layer separated, dried over Na2SO4, filtered and concentrated in vacuo to give 76.2 g of crude 1-chloro-3-[3-(trifluoromethyl)phenoxy]-2-propanol which was used in next step without additional treatment.

Provenance & Evidence