Hydrochloric Acid → HCID 69020040, compound

Participants

Reaction Steps

To a cooled solution (0° C.) of 4-amino resorcinol.HCl (1.0 g, 6.18 mmol) in H2O (10 mL) was added dropwise aq. NaOH (0.49 g, 12.3 mmol) in H2O (15 mL). To this mixture were added slowly Cbz-Cl (Carbobenzoxy chloride, 1.06 mL, 7.43 mmol) and NaOH (0.25 g) in H2O (5 mL). After stirring for 1 h at room temperature, the mixture was extracted with EtOAc (2×50 mL). The organic layer was dried over MgSO4 (10 g), filtrated and concentrated. The residue was purified by flash column chromatography on silica gel (EtOAc:hexane=1:5) to give (2,4-dihydroxyphenyl)-carbamic acid benzyl ester (KCBG02. 1.28 g, 80%).

Provenance & Evidence