Boric Acid → 1-Monopalmitin

HRID 1375314Notes

Reaction equation

Br[C:2]1[C:10]([CH3:11])=NC2N(N=CN=2)[C:3]=1O.[OH-].[Na+].C1[C@H](N[C@H:22]2[C@H:27](O)[C@@H:26](O)[C@@H:25]([O:30][C@@H:31]([C@H:36]([OH:41])[C@@H:37]([OH:40])C=O)[C@H](O)CO)[O:24][C@@H:23]2[CH2:42]O)[C@H](O)[C@@H](O)[C@H](O)C=1CO.B(O)(O)O>O>[CH3:11][CH2:10][CH2:2][CH2:3][CH2:42][CH2:23][CH2:22][CH2:27][CH2:26][CH2:25][CH2:42][CH2:23][CH2:22][CH2:27][CH2:26][C:25]([O:30][CH2:31][CH:36]([OH:41])[CH2:37][OH:40])=[O:24]

Participants

Conditions

Temperature: 50 °C

Procedure

Component D: A mixture of 5-bromo-4-hydroxy-6-methyl-1,3,3a,7-tetraazaindene, water, and 2.5N NaOH was placed in a beaker and heated to 50° C. to dissolve the materials and form Compound TAI-1. A mixture of boric acid and the indicated thermal solvent was dissolved in water by heating at 50° C. The solution was cooled to room temperature and a portion of deionized lime-processed gelatin was added to the solution to be hydrated for 30 minutes. The mixture was heated to 40° C. for 10 minutes to melt the gelatin. A portion of a dispersion of 6.5 μm polystyrene beads in gelatin was placed in another beaker and heated to 40° C. for 10 minutes to melt the gelatin. The two gelatin containing subcomponents were combined and the mixture was added a 4% active aqueous solution of ZONYL® FS-300 surfactant and a portion of the Compound TAI-1 solution described above.

Workup

temperatureby heating at 50° C
temperatureThe solution was cooled to room temperature
additionwas added to the solution
temperatureThe mixture was heated to 40° C. for 10 minutes
temperatureheated to 40° C. for 10 minutes
additionThe two gelatin containing subcomponents

Sources & evidence

ORD record: ord-38c0177965f947d4889c324f6ca9f375
Source dataset: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07169544B2

Reaction notes

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