Acetic Acid → HCID 86587851, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,6-dibromo-4-(2-benzyloxycarbonylethyl)-phenyl acridine-9-carboxylate (191 mg, 0.309 mmol), glacial acetic acid (20 ml) and 48% hydrobromic acid (5 ml) was heated at 100° C. for 3 h and then cooled. The mixture was added to water (100 ml) and extracted with 20% methanol in chloroform (100 ml×4). The organic extracts were combined and evaporated and the residue was suspended in chloroform (50 ml) and neutralised with a slight excess of triethylamine. The mixture was washed with water (70 ml×3), and the organic layer was dried over sodium sulphate and evaporated to dryness. The residue was recrystallised from CHCl3 to give the desired product (115 mg, 74%.), mp 240–2° C. FAB-MS m/z 529 [M+, 75%], 511 [10], 486 [10], 207 [100].

Provenance & Evidence