Dicyclohexylcarbodiimide → HCID 86587853, compound

Participants

Reaction Conditions

Reaction Steps

N-Hydroxysuccinimide (12 mg, 0.10 mmol) and 2,6-dibromo-4-(2-carboxyethyl)phenyl acridine-9-carboxylate (50 mg, 0.090 mmol) were dissolved in anhydrous DMF (3 ml) and cooled to −20° C. Dicyclohexylcarbodiimide (DCC, 22 mg, 0.11 mmol) was added and the mixture was stirred at −20° C. for 2 h. The solution was stirred overnight at room temperature, and then evaporated to dryness. The residue was extracted with dichloromethane (50 ml) and the filtrate was evaporated to obtain the crude product (100 mg). Further purification was carried out by chromatotron, eluted with chloroform. The solvent was evaporated from the appropriate combined fractions to give the desired product as a light-brown solid (40 mg, 64%), mp 175–6° C. FAB-MS m/z 627 [(M+1)+, 20%], 225 [100], 206 [18], 179 [10], 143 [8].

Provenance & Evidence