2-Propanone, 1-(3,4-dimethoxyphenyl)- → 3,4-Dma, (R)-

HRID 1375322Notes

Reaction equation

HRID 1375322 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][C:12](=O)[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].C1([C@H]([NH2:23])C)C=CC=CC=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][C@H:12]([NH2:23])[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 698962-Propanone, 1-(3,4-dimethoxyphenyl)-HCID 6431891-Phenethylamine, (+)-

Product 1

HCID 117694083,4-Dma, (R)-Yield 71.6%

Procedure

Using 10 ml of the above cell-free extract, the mixture was reacted in a 100 ml reaction mixture comprising 0.1 M Tris-hydrochloric acid buffer (pH 8.5) containing 0.5 g 1-(3,4-dimethoxyphenyl)-2-propanone and 0.34 g (R)-1-phenylethylamine at 30° C. for 24 hours. As a result, 0.36 g (R)-(3,4-dimethoxyphenyl)-2-aminopropane was formed.

Workup

  1. extractionextract
  2. customthe mixture was reacted in a 100 ml reaction mixture comprising 0.1 M Tris-hydrochloric acid buffer (pH 8.5)

Sources & evidence

ORD record
ord-be10205f5ed941b3aea95d732fc2aaf4
Source dataset
uspto-grants-2007_01
Patent number
US07169592B2

Reaction notes

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