Sodium Carbonate → HCID 6514828, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 6-methoxy-1-tetralone (5.0 g) in ethanol (100 mL) was treated with hydroxylamine hydrochloride (2.0 g) and sodium carbonate (3.6 g). The reaction mixture was heated overnight at 80° C. Cooled to room temperature after twenty hours, transferred to a 300 mL flask and concentrated. The residue was triturated in water and filtered to yield the title product as a brown solid (5.3 g) 1H NMR (400 MHz, CDCl3) 1.84–1.87(m, 2H), 2.72(t, J=6.2 Hz, 2H), 2.79(t, J=6.6 Hz, 2H), 3.80(s, 3H), 6.65(d, J=2.6 Hz, 1H), 6.76(dd, J=11.5, 2.7 Hz, 1H), 7.86 (d, J=8.8 Hz, 1H)

Provenance & Evidence