HCID 178423633, compound → HCID 69423825, compound

Participants

Reaction Steps

A solution of (3R)-1-[2-(6,8-dimethyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-2-oxoethyl]-3-(1H-indazol-3-ylmethyl)-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione (50 mg) in ethyl acetate (8 mL) was treated with 10% palladium on charcoal (300 mg). Placed under H2 environment (by balloon) and stirred at room temperature for 48 hours. Filtered through celite and concentrated to dryness. Chromatographed on silica gel (Hexane:Ethyl Acetate). Lyophilized the residue to yield the title compound as a white solid (6.6 mg)

Provenance & Evidence