HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1375390Generated: November 3, 2026
Benzenamine, 4-(4-morpholinyl)- → 4-(Methylamino)-2-[(4-morpholinophenyl)amino]-5-nitropyrimidine
https://huagongshe.com/reaction/1375390
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzenamine, 4-(4-morpholinyl)- | HCID 75655 | — |
| Reactant | 2-chloro-N-methyl-5-nitropyrimidin-4-amine | HCID 7147232 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(Methylamino)-2-[(4-morpholinophenyl)amino]-5-nitropyrimidine | HCID 21077572 | 98.1% |
Reaction Steps
To a room temperature solution of 0.943 g (5 mmol) of 2-chloro-4-(methylamino)-5-nitropyrimidine in 25 mL THF is added a solution of 1.96 g (11 mmol) of 4-(4-aminophenyl)morpholine in 100 mL of 2-propanol, and the resulting mixture is heated and stirred at 50° C. for 30 minutes. The mixture is then diluted with water, the solid precipitate is collected, washed with water, and dried, to give 1.62 g (98%) of the title compound: mp (EtOH) 240–241° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07169778B2 |
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| Source dataset | uspto-grants-2007_01 |
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| ORD ID | ord-f332a0c8d2b14233babc4f79904b6635 |
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| Source note | uspto-grants-2007_01 |
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