HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylaniline → HCID 58786816, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylaniline | HCID 949 | — |
| Reactant | 2-chloro-N-cyclopentyl-5-nitropyrimidin-4-amine | HCID 7147253 | — |
| Reactant | 1,1-Dimethylethyl N-[1-(4-aminophenyl)-3-pyrrolidinyl]carbamate | HCID 44607633 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58786816 | HCID 58786816 | 100.3% |
Reaction Steps
To a solution of 0.41 g (1.69 mmol) of 2-chloro-4-(cyclopentylamino)-5-nitropyrimidine and 0.25 g (2 mmol) N,N-dimethylaniline in 10 mL THF is added a solution of 0.47 g (1.69 mmol) of 3-(tert-butoxycarbonylamino)-1-(4-aminophenyl)pyrrolidine in 10 mL of 2-propanol, and the resulting mixture is heated under reflux for 2 hours. After cooling and acidification with acetic acid, the mixture is diluted with water to give 0.82 g (100%) of the title compound: mp (MeOH) 186–189° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07169778B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-3e589cc2df6048f5a59c30bb91233672 |
| Source note | uspto-grants-2007_01 |