HCID 58786816, compound → HCID 58786810, compound

HRID 1375406Notes

Reaction equation

HRID 1375406 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([NH:20][C:21]3[N:26]=[C:25]([NH:27][CH:28]4[CH2:32][CH2:31][CH2:30][CH2:29]4)[C:24]([N+:33]([O-])=O)=[CH:23][N:22]=3)=[CH:16][CH:15]=2)[CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd]>[NH2:33][C:24]1[C:25]([NH:27][CH:28]2[CH2:29][CH2:30][CH2:31][CH2:32]2)=[N:26][C:21]([NH:20][C:17]2[CH:16]=[CH:15][C:14]([N:11]3[CH2:12][CH2:13][CH:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:10]3)=[CH:19][CH:18]=2)=[N:22][CH:23]=1

Participants

3

Reactant 1

HCID 58786816HCID 58786816, compound

Product 1

HCID 58786810HCID 58786810, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Hydrogenation of 2-[[4-[3-(tert-butoxycarbonylamino)pyrrolidin-1-yl]phenyl]amino]-4-(cyclopentylamino)-5-nitropyrimidine (from Example 2(10) above) over Pd/C gave the title compound as a solid.

Sources & evidence

ORD record
ord-5bcc8fab7f084dea9db76fe084a807ff
Source dataset
uspto-grants-2007_01
Patent number
US07169778B2

Reaction notes

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