HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 6-(3,5-Dichloro-2,6-dimethoxypyridin-4-yl)-8-methyl-2-[[4-(morpholin-4-yl)phenyl]amino]-8H-pteridin-7-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Ethyl 2-(3,5-dichloro-2,6-dimethoxypyridin-4-yl)-2-oxoacetate | HCID 58786806 | — |
| Reactant | 5-Amino-4-(methylamino)-2-[[4-(morpholin-4-yl)phenyl]amino]pyrimidine | HCID 58786812 | — |
| Solvent | 2-Methoxyethanol | HCID 8019 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 6-(3,5-Dichloro-2,6-dimethoxypyridin-4-yl)-8-methyl-2-[[4-(morpholin-4-yl)phenyl]amino]-8H-pteridin-7-one | HCID 9937249 | 51% |
Reaction Steps
A mixture of 0.60 g (2 mmol) of 5-amino-4-(methylamino)-2-[[4-(morpholin-4-yl)phenyl]amino]pyrimidine, 1.23 g (4 mmol) of ethyl 2-(3,5-dichloro-2,6-dimethoxypyridin-4-yl)-2-oxoacetate, and 1 mL HOAc in 20 mL 2-methoxyethanol is heated under reflux for 16 hours. Workup in EtOAc, followed by chromatography on silica, eluting with hexane-EtOAc (3:2), gives 0.55 g (51%) of the title compound (Compound 18): mp (EtOH) 275–276° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07169778B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-0d103547f9434475ab960c980fbc54a4 |
| Source note | uspto-grants-2007_01 |