HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 6-(3,5-Dichloro-2,6-dimethoxypyridin-4-yl)-8-methyl-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8H-pteridin-7-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 5-Amino-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-4-(methylamino)pyrimidine | HCID 58786778 | — |
| Reactant | Ethyl 2-(3,5-dichloro-2,6-dimethoxypyridin-4-yl)-2-oxoacetate | HCID 58786806 | — |
| Solvent | 2-Methoxyethanol | HCID 8019 | — |
| Product | 6-(3,5-Dichloro-2,6-dimethoxypyridin-4-yl)-8-methyl-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8H-pteridin-7-one | HCID 9872923 | 51.4% |
Reaction Steps
A mixture of 0.66 g (2 mmol) of 5-amino-2-[[4-[2-(diethylamino)-ethoxy]phenyl]amino]-4-(methylamino)pyrimidine, 1.23 g (4 mmol) of ethyl 2-(3,5-dichloro-2,6-dimethoxypyridin-4-yl)-2-oxoacetate, and 1 mL of HOAc in 20 mL of 2-methoxyethanol is heated under reflux for 16 hours. Workup as in 6 above gives 0.59 g (51%) of the title compound (Compound 21): mp (EtOH) 239–240° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07169778B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-046c487b1e5a4b4ebc73aa4e44f14092 |
| Source note | uspto-grants-2007_01 |