HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 6-(3,5-Dichloro-2,6-dimethoxypyridin-4-yl)-2-[[4-(diethylamino carbonyl)phenyl]amino]-8-methyl-8H-pteridin-7-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 5-Amino-2-[[4-(diethylaminocarbonyl)phenyl]amino]-4-(methylamino)pyrimidine | HCID 58786782 | — |
| Reactant | Ethyl 2-(3,5-dichloro-2,6-dimethoxypyridin-4-yl)-2-oxoacetate | HCID 58786806 | — |
| Solvent | 2-Methoxyethanol | HCID 8019 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 6-(3,5-Dichloro-2,6-dimethoxypyridin-4-yl)-2-[[4-(diethylamino carbonyl)phenyl]amino]-8-methyl-8H-pteridin-7-one | HCID 9872467 | 56% |
Reaction Steps
A mixture of 0.47 g (1.5 mmol) of 5-amino-2-[[4-(diethylaminocarbonyl)-phenyl]amino]-4-(methylamino)pyrimidine, 0.62 g (2 mmol) of ethyl 2-(3,5-dichloro-2,6-dimethoxypyridin-4-yl)-2-oxoacetate and 1.0 mL of HOAc in 20 mL of 2-methoxyethanol is heated under reflux for 16 hours. Workup in EtOAc, followed by chromatography on silica, eluting with hexane/EtOAc (1:1), gives 0.42 g (56%) of the title compound (Compound 22): mp (EtOH) 274–276° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07169778B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-726f9ae4cf564924923ad09410c4131c |
| Source note | uspto-grants-2007_01 |