HCID 22583463, compound → HCID 58787186, compound

Participants

Reaction Steps

A suspension of 5-[(4-methylpiperazin-1-yl)sulfonyl]indoline (1-7, 8.00 g, 28.4 mmol, 1 equiv) and MnO2 (8.00 g, 92.0 mmol, 3.24 equiv) in dichloromethane (300 mL) was heated at reflux for 1 hour. More MnO2 (8.00 g, 92.0 mmol, 3:24 equiv) was added, and the resulting suspension was heated for 2 hours. The manganese oxides were filtered off onto a pad of celite and washed with dichloromethane (500 mL). The filtrate was concentrated to give 5-[(4-methylpiperazin-1-yl) sulfonyl]-1H-indole (1-8) as a white solid. 1H NMR (300 MHz, CDCl3) δ 8.59 (br s, 1H), 8.10 (d, 1H, J=1.8 Hz), 7.55 (dd, 1H, J=8.5, 1.8 Hz), 7.46 (d, 1H, J=8.5 Hz), 7.34 (m, 1H), 6.67 (m, 1H), 3.04 (br m, 4H), 2.48 (br t, 4H, J=4.9 Hz), 2.25 (s, 3).

Provenance & Evidence