HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → tert-Butyl 3-cyanomorpholine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Trifluoroacetic anhydride | HCID 9845 | — |
| Reactant | tert-Butyl 3-carbamoylmorpholine-4-carboxylate | HCID 21098189 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | tert-Butyl 3-cyanomorpholine-4-carboxylate | HCID 21098190 | — |
Reaction Steps
A solution of the product of Step 2 (1 eq.) and triethylamine (2.1 eq.) in CH2Cl2 (0.1 M) was cooled to 0° C. and trifluoroacetic anhydride (1.1 eq.) added dropwise under nitrogen. Stirring was continued 3.5 hours more at room temperature and volatiles removed in vacuo. Residues taken in EtOAc were washed with water, brine and dried over Na2SO4. Evaporation gave the title compound as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07169780B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-2b3026891f6e4003b936e4de2c9e9ad9 |
| Source note | uspto-grants-2007_01 |