Trifluoroacetic acid methylene chloride → HCID 54677504, compound

HRID 1375536Notes

Reaction equation

HRID 1375536 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH:9]1[C:14]1[N:15]([CH3:33])[C:16](=[O:32])[C:17]([OH:31])=[C:18]([C:20]([NH:22][CH2:23][C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)=[O:21])[N:19]=1)=O)(C)(C)C.ClCCl.C(O)(C(F)(F)F)=O>>[F:30][C:27]1[CH:28]=[CH:29][C:24]([CH2:23][NH:22][C:20]([C:18]2[N:19]=[C:14]([CH:9]3[CH2:10][O:11][CH2:12][CH2:13][NH:8]3)[N:15]([CH3:33])[C:16](=[O:32])[C:17]=2[OH:31])=[O:21])=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 54677508HCID 54677508, compound

Product 1

HCID 54677504HCID 54677504, compound

Procedure

The compound from Step 9 was treated with a mixture of dichloromethane/TFA (2/1) for 1 hour at room temperature. Organics were removed in vacuo to give the title compound as a solid.

Workup

  1. customOrganics were removed in vacuo

Sources & evidence

ORD record
ord-725ccfbcf5e94aaea38444e8f20a0b86
Source dataset
uspto-grants-2007_01
Patent number
US07169780B2

Reaction notes

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