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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1375552Generated: October 30, 2026

Triethylamine → Benzyl (2S,4S)-2-cyano-4-fluoropyrrolidine-1-carboxylate

https://huagongshe.com/reaction/1375552

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethylamineHCID 8471—
ReactantTrifluoroacetic anhydrideHCID 9845—
ReactantHCID 58136204HCID 58136204—
SolventDichloromethaneHCID 6344—
ProductBenzyl (2S,4S)-2-cyano-4-fluoropyrrolidine-1-carboxylateHCID 23626152—

Reaction Steps

Benzyl-(2S,4S)-2-aminocarbonyl-4-fluoropyrrolidine-1-carboxylate in dichloromethane was treated at 0° C. with Et3N (2.1 eq.) and trifluoroacetic anhydride was added dropwise.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07169780B2
Source datasetuspto-grants-2007_01
ORD IDord-1cceeac9fe1c440cbdd0c87f5ac41465
Source noteuspto-grants-2007_01