HCID 54677605, compound → HCID 54677480, compound

HRID 1375560Notes

Reaction equation

HRID 1375560 reaction equation
C(OC([N:11]1[CH2:15][C@H:14]([O:16][CH3:17])[CH2:13][C@H:12]1[C:18]1[N:19]([CH3:37])[C:20](=[O:36])[C:21]([OH:35])=[C:22]([C:24]([NH:26][CH2:27][C:28]2[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=2)=[O:25])[N:23]=1)=O)C1C=CC=CC=1>CO.[Pd]>[F:34][C:31]1[CH:30]=[CH:29][C:28]([CH2:27][NH:26][C:24]([C:22]2[N:23]=[C:18]([C@@H:12]3[CH2:13][C@@H:14]([O:16][CH3:17])[CH2:15][NH:11]3)[N:19]([CH3:37])[C:20](=[O:36])[C:21]=2[OH:35])=[O:25])=[CH:33][CH:32]=1

Participants

4

Reactant 1

HCID 54677605HCID 54677605, compound

Product 1

HCID 54677480HCID 54677480, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Benzyl-(2S,4R)-2-(4-{[(4-fluorobenzyl)amino]carbonyl}-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-4-methoxypyrrolidine-1-carboxylate was dissolved in methanol and Pd/C 10% wt (14% w/w) was added. The mixture was stirred under H2 atmosphere at room temperature. After 2 hours the reaction mixture was filtered and methanol was removed in vacuo to give title compound.

Workup

  1. filtrationAfter 2 hours the reaction mixture was filtered
  2. custommethanol was removed in vacuo

Sources & evidence

ORD record
ord-65d8a9ab176346e7af0bfa0b9faf37ca
Source dataset
uspto-grants-2007_01
Patent number
US07169780B2

Reaction notes

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