HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → benzyl N-(2-cyanopropan-2-yl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | 2-Amino-2-methylpropionitrile | HCID 88022 | — |
| Solvent | Water | HCID 962 | — |
| Product | benzyl N-(2-cyanopropan-2-yl)carbamate | HCID 18442523 | — |
Reaction Steps
To a suspension of 2-amino-2-methylpropanenitrile in water an equimolar amount of Na2CO3 and a slight excess (1.1 eq) of benzylchloroformate were added, with an external cooling. Reaction mixture was stirred o/n at room temperature, extracted in EtOAc and the organic phase was washed with NaHCO3ss, dried (Na2SO4), filtered and concentrated. Product was obtained as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07169780B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-03a8aaeebef04b5e92f10c96722291b4 |
| Source note | uspto-grants-2007_01 |