[3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester → 3-(2-Methyl-1H-imidazole-1-yl)-5-(trifluoromethyl)aniline

HRID 1375608Notes

Reaction equation

HRID 1375608 reaction equation
[CH3:1][C:2]1[N:3]([C:7]2[CH:8]=[C:9]([NH:17]C(=O)OC(C)(C)C)[CH:10]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:12]=2)[CH:4]=[CH:5][N:6]=1.N1(C2C=C(NC(=O)OC(C)(C)C)C=C(C(F)(F)F)C=2)CCOCC1>>[CH3:1][C:2]1[N:3]([C:7]2[CH:12]=[C:11]([C:13]([F:16])([F:14])[F:15])[CH:10]=[C:9]([NH2:17])[CH:8]=2)[CH:4]=[CH:5][N:6]=1

Participants

3

Reactant 2

HCID 86605432[3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl esterHCID 86606802(3-Morpholin-4-yl-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

Product 1

HCID 667757113-(2-Methyl-1H-imidazole-1-yl)-5-(trifluoromethyl)aniline

Procedure

Utilising the procedure described in Example 90c but employing [3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester (Example 91c) in lieu of [3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester, afforded the title compound as a yellow crystalline solid, m.p. 130–133° C.

Sources & evidence

ORD record
ord-4a4a6cae727a4792a69d60d22989c77d
Source dataset
uspto-grants-2007_01
Patent number
US07169791B2

Reaction notes

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